Service
Middle-molecular
drugsContract manufacturing
We have built a CRDMO system that can handle
feverything from raw materials to APIs,
from the R&D stage to the manufacturing stage.
Service contents
Contract manufacturing services
The large-scale production will be carried out at the Naruto Factory of Syncrest, a multi-purpose, multi-product plant for high-pharmacological activity (OEB Category4) GMP that can be produced using continuous flow synthesis as well as batch-and solid-phase synthesis.
Library of materials for synthesis of middle molecules
We have a library of compounds containing over 100 types of non-natural amino acids, non-natural amidites, small ring compounds, etc.
We will respond to the diverse needs of drug discovery research
with Syncrest's technologies.
- Contract manufacturing of
middle
molecules(peptides, nucleic acids, lipids, sugar chains, etc.) - Contract manufacturing of
middle-molecular synthetic raw materials(amino acids, amidites, etc.)
Contract manufacturing of
middle molecules(peptides, nucleic acids, lipids,
sugar chains, etc.)
We support integrated manufacturing and quality control
from raw materials to APIs, including synthetic method development, various modifications,
analysis, analytical method development, separation study of related compounds,
method validation, and stability testing.
Custom synthesis of
peptides
| Laboratory Synthesis |
GMP Production |
|
|---|---|---|
| Structure | Linear, Cyclic, S-S Cross-Linking |
|
| Side Chain |
Natural & Non-Natural | |
| N-Modification | Methylation, Ethylation | |
| Other Modification |
Conjugate (Nucleic Acid, Lipid, Glycan, etc.) |
|
| Conjugated Salt |
TEA Salt, HCl Salt, etc. | |
| Synthetic Amount |
Several mg-g |
Several g-Several Hundred g |
Peptides
Wide range of applications available from short chains to long chains, cyclization, and special modifications.
-
di
Amide bond
Disulfide bond
Click bond
....
etc.
-
N-alkylation
-
D-amino acid
-
β-amino acid
Various other non-natural modifications are also possible.
Introduction of non-natural monomers (commissioned synthesis of non-natural amino acids is also possible)
Conjugate modifications (nucleic acids, lipids, sugar chains, etc.)
Custom synthesis of
nucleic acids
| Lab synthesis |
GMP production |
|
|---|---|---|
| structure | single-stranded, double-stranded, NDA/RNA hetero | |
| nucleobase | natural & non-natural (amidite consignment available) |
|
| sugar modification |
2'OR, cross-linked | |
| phosphate modification |
PO/PS/ chimera | |
| other modifications |
conjugate, etc. (peptide/lipid/glyacan, etc.) |
|
| conjugated salt |
TEA salt, Na salt, etc. | |
| synthetic quantity |
several mg-several grams | several g-several tens of grams |
Acids
Wide range of applications available from short chains to long chains, cyclization, and special modifications.
-
Base-backbone
....
etc.
-
Phosphate-backbone
P=S modification 
-
Sugar-backbone modifications
RNA type 
2'-OR 
Fluorination 
Cross-linked type 
Seleno type 
Various other non-natural modifications are also possible.
Introduction of non-natural monomers (commissioned synthesis of non-natural amidites is also possible)
Conjugate modifications (nucleic acids, lipids, sugar chains, etc.)
| Main analysis equipments | |
|---|---|
| LC/MS/MS (Thermo Fischer, Orbitrap Eclipse) |
NMR (Bruker, 500 MHz) |
| MALDI-TOF MS (Bruker, Autoflex) | Toxinometer |
| LC/MS (Waters, BioAccord) |
Organic elemental analyzer |
| UPLC (Waters, I-class) |
FT-IR (Shimadzu Corporation) |
| UHPLC (Waters, H-class) | Polarimeter (Anton Paar) |
| HPLC (Waters, Alliance) | UV spectrophotometer (Shimadzu Corporation) |
| GC/MS (Shimadzu Corporation) | Ion chromatography (Shimadzu Corporation) |
| HS-GC (Shimadzu Corporation) | TOC analyzer |
-
Automated oligonucleotide synthesizer(Cytiva, OligoSynt®)© 2022 Cytiva - Reproduced by permission of the owner
-
LC/MS/MS(Thermo Fischer, Orbitrap Eclipse)
Contract manufacturing of
middle-molecular synthetic
raw materials(amino acids, amidites, etc.)
We offer high-quality raw materials for medium-molecule synthesis
through a batch/flow synthesis technology of Syncrest.
Characteristics of Syncrest's raw materials for the synthesis of
middle molecules
Syncrest combines organic synthesis technology, process development technology, and halogenation technology to synthesize new non-natural amino acids and non-natural amidites.
In addition to the batch synthesis method, we utilize the most advanced flow synthesis method to realize the synthesis of non-natural amino acids and non-natural amidites with high quality and short delivery time.
We also build libraries of hundreds of non-natural amino acids and non-natural amidites.
Please use it for drug discovery and library screening.
- non-natural amino acid
- non-natural amidites
- sugar chains
- lipids
Automated library synthesis using robots
Non-natural amino acid
We can synthesize from common amino acids to non-natural
amino acids that are unknown in the literature and not listed in CAS.
Typical examples
-
N-alkylation
-
b-substitution
-
non-naturally protected
-
fluorinated
-
Phe derivatives
In addition, various non-natural amino acids can be synthesized.
Non-natural amidites
We can synthesize from common amidites to non-natural
amidites that are unknown in the literature and not listed in CAS.
Typical examples
-
2'-OR
-
fluorinated, bridged
-
bridged
-
non-natural base types
Various other non-natural amidites can be synthesized.
