Bases
R&D division equipped with the latest facilities in Fujisawa City, Kanagawa Prefecture and production control centers (Naruto City, Tokushima Prefecture) are linked.
Shonan laboratory
We continue to search for seeds and create core technologies together with our partners, with open innovation and the creation of a next-generation research environment as key concepts, It is possible to undertake consistently from the synthesis of various small molecules including non-natural amino acids and amidites to peptide synthesis and nucleic acid synthesis.
Naruto Factory
Installation of multi-production facilities for small-to medium-volume production of a wide variety of products capable of handling highly active drug substances (OEB4) from Non-GMP to GMP to conventional batch-to-flow synthesis, It can be manufactured on mg ~ kg flexible-scale from general small molecules including non-natural amino acids and nucleic acid monomers to middle molecules such as peptides, nucleic acids, and sugar chains.
Naruto multiple APIs (NMA) plant
A high pharmacologically active (OEB Category-4) GMP multi-purpose plant capable of solid-phase synthesis/flow synthesis provides consistent servicing from non-naturalty raw materials to intermediates to mid-molecule drug substances.
Please feel free to contact us for the production of highly active medium-molecular drugs.
| Control level | Equipment | Capacity and specifications | Quantity | Remarks |
|---|---|---|---|---|
| Non-GMP | Solid phase synthesizer | 20 L | 1 | |
| HPLC | 1 | Shimadzu | ||
| GC | 1 | Shimadzu | ||
| Preparative chromatography system | 150 mL/ min | 1 | ||
| 1,000 mL/ min | 1 | |||
| Centrifugal separator | 6 L/ 12000 G | 1 | ||
| Membrane concentrator | 50 L/ h | 1 | ||
| Evaporator | 20 L | 1 | ||
| Freeze dryer | 3 L | 2 | ||
| 20 L | 1 |
| Control level | Equipment | Capacity and specifications | Quantity | Remarks |
|---|---|---|---|---|
| GMP OEB Category 4 |
Solid phase synthesizer | 30 L | 1 | GL |
| 10 L | 1 | GL | ||
| Automated oligonucleotide synthesizer | OligoSynt® (12 mmol) | 1 | Cytiva | |
| High pressure chromatography system | 1.5 L/ min | 1 | YMC | |
| Medium pressure chromatography system | 1 L/ min | 1 | Biotage | |
| Low pressure chromatography system | 0.6 L/ min | 1 | Cytiva | |
| High pressure column | Inner diameter: 100 mm | 1 | Reversed phase large-scale preparative purification system, SUS | |
| Inner diameter: 150 mm | 1 | |||
| Reactor | 30 L | 1 | GL | |
| Evaporator | 30 L | 2 | GL | |
| Membrane concentrator | 30 L/ h | 1 | Cytiva | |
| Freeze dryer | Condenser Capacity: 35 L |
1 | Shelf type | |
| 1 | ||||
| Purified water production system | 300 L/ h (25℃) | 2 | RO + UF membrane + Ion exchange |